Research & IUI Lab

Research & IUI Lab


   Fertility Research and Practice is a peer-reviewed, open access, online journal, publishing articles that provide novel insights into male and female infertility and early pregnancy.

   Fertility Research and Practice aims to elucidate the broad range of topics comprising the study of human fertility and early pregnancy. These include diagnosis and correction of endometriosis, congenital and acquired abnormalities of the male and female reproductive tracts, reproductive infectious diseases, male and female fertility diagnostics, assisted reproductive techniques (ART), implantation and early pregnancy failure, pregnancy of unknown location, and sporadic and recurrent pregnancy loss. Understanding that the study of human fertility and early pregnancy often involves in vitro, ex vivo and animal models for ethical and legal reasons, Fertility Research and Practice invites basic science in addition to clinical and translational research. Approaches that apply cutting-edge technologies to problems in the field are especially welcome.

Intrauterine Insemination (IUI)

During a normal regular ovulatory cycle, one follicle develops per month from either ovaries.

Ovum is released from the mature follicle after rupture. It travels through the patent Fallopian tube.

If intercourse happens at this time and semen parameters are normal, sperms travel through the uterus to reach ovum in tube and Fertilization takes place.

Embryo formed travels back to the uterine cavity for implantation.

Unexplained infertility –

IUI is advised in unexplained infertility along with medications that induce ovulation.

Infertility due to endometriosis –

during endometriosis by giving medication for healthy egg production and opting for IUI can increase the chances of conception.

Infertility due to cervical issues –

scarring or mucosal problems can be the reason for infertility. IUI bypasses the cervix and allows the sperms to enter into the uterus directly, thus increases the number of sperms available for fertilization.


Semen Wash Unit

The male-factor causing infertility –
During low sperm count, decreased sperm motility, or ejaculation problems, IUI can be used. IUI allows choosing healthy motile sperms that increases the chances of fertilization.

Intrauterine Insemination (IUI) Procedure/technique

IUI is a painless, non-invasive procedure, and it can also be done with your natural cycle without using medication. During your ovulation, sperms collected from your partner are used for IUI.

However, IUI can also be combined with ovarian stimulation medications such as Human Chorionic Gonadotropin (HCG) and Follicular Stimulating Hormone (FSH). This results in the production and release of multiple eggs, increasing the chances of conception.

Your fertility clinic and the doctor will have specific instructions to follow for the IUI procedure.

  • You may have to visit your fertility clinic during menstruation for the blood test, ultrasound, and to receive instructions about medications.
  • If medications are needed, you will be advised to start your medications during your menstrual cycle.
  • After a week, you will be called for an ultrasound and blood test.
  • Depending on your test results, you will be called to examine if you are ovulating, which is after 10 to 15 days of starting your medications.
  • Semen samples from your partner will be collected on the day of the procedure or well before, and stored.
  • Sperms will be washed to remove seminal fluid and other debris.
  • IUI does not require anesthesia; it is a quick procedure and is less painful.
  • You will be made to lie down. Your doctor will use a speculum to open the vagina gently.
  • The sperms will be inserted into the uterus using a long and thin tube.
  • You will be advised to relax in a reclined position for about thirty minutes.
  • You might experience slight discomfort or mild cramping during the procedure. Sometimes spotting or vaginal bleeding is also seen.
  • You will be asked to take a pregnancy test two weeks after the IUI procedure.